Ongoing Clinical Trials
in Critical Care
UCSF is home to a wide range of critical care clinical trials designed to improve outcomes for patients with life-threatening illness. These studies test new treatments, interventions, and care strategies that bring the latest scientific discoveries directly to the bedside. Explore our actively recruiting studies below.
ARRC
(Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children)
CPR-CC Faculty Involved: Matt Zinter, MD
Enrolling Sites: UCSF Benioff Children's Hospitals
The proposed study will be a randomized, double-blinded, placebo-controlled Phase III trial to examine the efficacy of AZM therapy relative to placebo in reducing RSV-related morbidity. Patients will be recruited during acute hospitalization and admission to the ICU at 10 pediatric hospitals. The target population selected is pediatric patients with severe RSV lung disease as defined by need for ICU management and intensive respiratory support. Contact: [email protected]
AURORA
(Adipose Derived Stem Cells for Urinary Recovery and Organ Repair in AKI)
CPR-CC Faculty Involved: Lucy Kornblith, MD
Enrolling Sites: Zuckerberg San Francisco General
A multicenter, prospective, randomized, double-blind, placebo-controlled pragmatic Phase 1/Phase 2 clinical trial to determine safety and effectiveness, the potential use of adipose-derived allogenic MSCs to prevent progression of trauma-induced acute kidney injury (AKI). Contact: [email protected]
CAVALIER
(CAlcium and VAsopressin following Injury Early Resuscitation trial)
CPR-CC Faculty Involved: Lucy Kornblith, MD
Enrolling Sites: Zuckerberg San Francisco General
A multicenter, prehospital, randomized, double-blinded, clinical trial comparing fentanyl versus sub-dissociative ketamine for mortality outcome differences, safety and analgesia in trauma patients with compensated shock. Contact: [email protected]
FEEDS
(Fasting Preprocedurally in Enteral Nutrition: Evaluation of Divergent Approaches in Secure Airway)
Enrolling Sites: UCSF Parnassus and Mission Bay
- mechanically ventilated
- receiving tube feeds at above trickle rate
- have an eligible and planned therapeutic (OR, IR, bedside) or diagnostic procedure (MRI, CT, TEE, angiogram, bronchoscopy, etc)
Contact: [email protected]
IC-SARI
CPR-CC Faculty Involved: Michael Matthay, MD
Enrolling Sites: UCSF Parnassus
This is a project conducted using the STRIVE Observational master protocol. This study will enroll adults with a moderate-to-severe immunocompromising condition who are admitted to the hospital with a severe acute respiratory infection (SARI). The study will advance knowledge on the pathogens most commonly causing SARI among immunocompromised adults globally and provide information on the clinical outcomes of patients with these infections. Contact: [email protected] and [email protected]
PAIN
CPR-CC Faculty Involved: Lucy Kornblith, MD
Enrolling Sites: Zuckerberg San Francisco General
A multicenter, prospective, randomized, double-blind, placebo-controlled pragmatic Phase 1/Phase 2 clinical trial to determine safety and effectiveness, the potential use of adipose-derived allogenic MSCs to prevent progression of trauma-induced acute kidney injury (AKI). Contact: [email protected]
PANTHER-US
CPR-CC Faculty Involved: Carolyn Calfee, MD MAS, Michael Matthay, MD
Enrolling Sites: UCSF Parnassus
Enrolling soon: A global precision medicine Phase 2 platform trial, using real-time biological phenotyping to identify hyperinflammatory and hypoinflammatory phenotypes of ARDS in adult patients, and testing simvastatin or baricitinib as compared to usual care.
P-ICECAP
(Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients)
CPR-CC Faculty Involved: Matt Zinter, MD
Enrolling Sites: UCSF Benioff Children’s Hospitals
This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest. Contact: [email protected]
PRACTICAL DRIVE
Invasive Mechanical Ventilation (IMV) Strategies
CPR-CC Faculty Involved: Carolyn Calfee, MD MAS, Michael Matthay, MD
Enrolling Sites: UCSF Parnassus
Multicenter large randomized controlled trial for adult patients with acute hypoxemic respiratory failure comparing driving pressure-limited ventilation to conventional lung protective ventilation. Contact: [email protected] and [email protected]
PRECISE TRIPS
(Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS)
CPR-CC Faculty Involved: Matt Zinter, MD
Enrolling Sites: UCSF Benioff Children’s Hospitals
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS). Contact: [email protected]
PREVENT VILI
CPR-CC Faculty Involved: Michael Matthay, MD
Enrolling Sites: UCSF Parnassus
A phase III multi-centered, randomized controlled trial of mechanical ventilation, directed by driving pressure and esophageal manometry, in patients with moderate or severe ARDS. Contact: [email protected] and [email protected]
SHIPSS
(Stress Hydrocortisone in Pediatric Septic Shock)
CPR-CC Faculty Involved: Matt Zinter, MD
Enrolling Sites: UCSF Benioff Children’s Hospitals
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and vasoactive-inotropic refractory septic shock. Contact: [email protected]
STAR TRIAL
CPR-CC Faculty Involved: Michael Matthay, MD
Enrolling Sites: UCSF Parnassus
Enrolling soon: Clinical trial in ICU patients with ARDS and soon with patients hospitalized on the floor with mild and moderate respiratory failure in a blinded trial of glucocorticoids.