News & Events

Updates, scientific highlights, and recent publications from CPR-CC investigators

Research Seminars

The CPR-CC Seminar Series brings together researchers and clinicians from across UCSF and partner institutions to share advances in critical care medicine. The series highlights emerging discoveries, fosters collaboration, and showcases innovative approaches that advance precision science and improve outcomes for critically ill patients.

Pathobiology of Lung Injury after Stem Cell Transplantation: Lessons Learned from Patient Studies
Matt Zinter, MD

Monday, June 15, 2026 1:30pm

Carbocisteine or Hypertonic Saline for Acute Respiratory Failure: Results of the MARCH Trial
Danny McAuley, MD - Queen's University Belfast

Monday, July 6, 2026 1:30pm

Recent Manuscripts & Scientific Highlights

Recent publications from CPR-CC investigators advancing precision approaches to critical illness and recovery.

A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial

Liu et al.
JAMA 2026

A more conservative dialysis approach was linked to better kidney recovery in patients with dialysis-requiring acute kidney injury.

Why it matters: Less dialysis may help the kidneys recover sooner in selected patients.

Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study

Reddy et al.
Lancet Respir Med 2026

Real-time bedside identification of ARDS subphenotypes revealed distinct risk profiles and outcomes in critically ill patients.

Why it matters: Demonstrates the feasibility of applying precision medicine at the bedside to guide future targeted therapies.

Longitudinal multiomic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality

Alipanah-Lechner et al.
JCI 2025

Integrative multiomic profiling identified distinct molecular pathways linking ARDS and sepsis phenotypes to patient outcomes.

Why it matters: Identifying phenotype-specific biology may guide development of targeted therapies in critical illness.

Integrating a host biomarker with a large language model for diagnosis of lower respiratory tract infection

Phan et al.
Nat Commun 2025

Integrating a host biomarker with large language model analysis improved diagnostic accuracy for lower respiratory tract infection in critically ill patients.

Why it matters: Demonstrates how combining molecular data with AI could enable more precise and timely diagnosis in critical illness.

Center News

Melanie-Weingart

March 2026

CPR-CC Supports Recruitment of Dr. Melanie Weingart to ZSFG

The UCSF Center for Precision Research in Critical Care (CPR-CC) is pleased to announce its support of a new faculty recruitment at Zuckerberg San Francisco General Hospital (ZSFG), made possible through a collaborative funding partnership with the Nina Ireland Program for Lung Health. This joint effort reflects a shared commitment to advancing precision medicine in critical illness while strengthening the pipeline of physician-scientists working at the intersection of translational science and ICU care. It also reinforces a shared priority of expanding access to clinical trials at ZSFG and ensuring that advances in critical care reach the diverse patient populations it serves.  
 
Melanie Weingart, MD, a pulmonary and critical care physician-scientist trained under the mentorship of Drs. Carolyn Calfee and Michael Matthay, will join the faculty at ZSFG beginning July 1. Her research focuses on immunophenotyping in sepsis and ARDS using single-cell methods in both patients and mouse models to better understand heterogeneity in the host immune response and its relationship to clinical outcomes. In addition, her work will contribute to expanding new clinical trials at ZSFG with an emphasis on improving access to innovative critical care research for underserved populations. This recruitment underscores CPR-CC’s broader mission to support early-career investigators and to foster collaborative, cross-campus research environments that accelerate the implementation of precision approaches in critical care.

Patient & Researcher Stories

Researcher Spotlight

Dr. Lucy Kornblith

“My work is inspired by the urgency and human cost of traumatic injury, especially how bleeding and blood-system failure contribute to preventable deaths. At the Kornblith Lab we investigate the cellular and molecular mechanisms underlying trauma-induced coagulopathy, with the goal of identifying new diagnostic markers and therapeutic targets. We combine basic and translational science, large observational cohorts, and clinical trials to bridge mechanistic insight with real-world patient care. Research collaborations are essential: they allow us to access complementary expertise (in biostatistics, vascular biology, critical care, and beyond) and to assemble the patient cohorts and biospecimens necessary to test hypotheses in real injured populations.”
-Lucy Kornblith

Researcher Spotlight

Dr. Jon Singer

Originally featured by UCSF Health: ‘Catching His Breath’

“The story follows Bradley Dell, a young man who suffers from severe cystic fibrosis. The Hawaii native becomes so sick that his survival depends on whether he gets a double-lung transplant. Unfortunately, because he has a super bacterial infection, hospitals across the country turn him down for the surgery. When the UCSF transplant team learns about Bradley’s case, they realize they need to push the boundaries of what defines a transplant candidate.”

Bradley’s care and recovery involved members of the CPR-CC Core Faculty, including Dr. Jon Singer, whose research in patient-center outcomes in lung transplantation and cystic fibrosis continues to advance outcomes for patients with advanced lung disease and transplant cared for in intensive care units.

Researcher Spotlight

Dr. Jon Singer

Originally featured on SFGate: ‘Joyful wedding for lung transplant recipient’ – ‘Double lung transplant recipient uses songs at her wedding that she and her mother selected 5 years ago for her funeral’

This patient’s remarkable recovery was made possible through the dedication of UCSF’s critical care and transplant teams, including members of the CPR-CC Core Faculty, whose research and clinical expertise continue to advance care for patients with severe respiratory failure and complex transplant needs.

Events

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